snRNP sets RNA length

Cover for Cell
6 July, 2012
Volume 150, Issue 1

View the cover and the story 
on Cell website

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Sculpting a functional mRNA out of a pre-mRNA transcript involves coordination of multiple processing events, including pre-mRNA splicing and 3′ cleavage and polyadenylation.  U1 snRNP (U1) plays a key role in suppressing PAS usage throughout pre-mRNAs and that these interactions may serve regulatory functions.   The cover image depicts legions of U1 “defenders” protecting the nascent pre-mRNA (green) from the constant threat of cleavage and polyadenylation hordes riding on the tail of RNA pol II. The work was in collaboration with Dr. Gideon Dreyfuss.



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